Publications by Year: 2015

Köster, S. ; Weitz, D. A. ; Goldman, R. D. ; Aebi, U. ; Herrmann, H. Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks. Current Opinion in Cell Biology 2015, 32, 82-91.Abstract

Intermediate filament proteins form filaments, fibers and networks both in the cytoplasm and the nucleus of metazoan cells. Their general structural building plan accommodates highly varying amino acid sequences to yield extended dimeric α-helical coiled coils of highly conserved design. These ‘rod’ particles are the basic building blocks of intrinsically flexible, filamentous structures that are able to resist high mechanical stresses, that is, bending and stretching to a considerable degree, both in vitro and in the cell. Biophysical and computer modeling studies are beginning to unfold detailed structural and mechanical insights into these major supramolecular assemblies of cell architecture, not only in the ‘test tube’ but also in the cellular and tissue context.

Zieringer, M. A. ; Carroll, N. J. ; Abbaspourrad, A. ; Koehler, S. A. ; Weitz, D. A. Microcapsules for Enhanced Cargo Retention and Diversity. Small 2015, n/a–n/a. Publisher's Version 2015_small_microcapsules_for_cargo_retention.pdf
Polenz, I. ; Weitz, D. A. ; Baret, J. - C. Polyurea Microcapsules in Microfluidics: Surfactant Control of Soft Membranes. Langmuir 2015, 31, 1127–1134. Publisher's Version 2015_langmuir_polyurea_microcapsules.pdf

PMID: 25531127

Akartuna, I. ; Aubrecht, D. M. ; Kodger, T. E. ; Weitz, D. A. Chemically induced coalescence in droplet-based microfluidics. Lab Chip 2015, -. Publisher's VersionAbstract

We present a new microfluidic method to coalesce pairs of surfactant-stabilized water-in-fluorocarbon oil droplets. We achieve this through the local addition of a poor solvent for the surfactant{,} perfluorobutanol{,} which induces cohesion between droplet interfaces causing them to merge. The efficiency of this technique is comparable to existing techniques providing an alternative method to coalesce pairs of droplets.

Shimanovich, U. ; Efimov, I. ; Mason, T. O. ; Flagmeier, P. ; Buell, A. K. ; Gedanken, A. ; Linse, S. ; Åkerfeldt, K. S. ; Dobson, C. M. ; Weitz, D. A. ; et al. Protein Microgels from Amyloid Fibril Networks. ACS Nano 2015, Article ASAP. Publisher's Version [PDF]

PMID: 25469621