High throughput production of single core double emulsions in a parallelized microfluidic device

Citation:

Romanowsky, M. B. ; Abate, A. R. ; Rotem, A. ; Holtze, C. ; Weitz, D. A. High throughput production of single core double emulsions in a parallelized microfluidic device. Lab on a Chip 2012, 12, 802-807. Copy at http://www.tinyurl.com/kaxbt63
[PDF]1.19 MB

Abstract:

Double emulsions are useful templates for microcapsules and complex particles, but no method yet exists for making double emulsions with both high uniformity and high throughput. We present a parallel numbering-up design for microfluidic double emulsion devices, which combines the excellent control of microfluidics with throughput suitable for mass production. We demonstrate the design with devices incorporating up to 15 dropmaker units in a two-dimensional or three-dimensional array, producing single-core double emulsion drops at rates over 1 kg day(-1) and with diameter variation less than 6%. This design provides a route to integrating hundreds of dropmakers or more in a single chip, facilitating industrial-scale production rates of many tons per year.

Notes:

Times Cited: 25

Last updated on 04/17/2014