Development of biomimetic liposomes with cell membrane proteins for targeted delivery

Liposomes offer a popular platform for drug delivery. Conventional liposomes have a range of attractive properties, including having tunable surface properties and size. How to further endow liposomes more efficient and target?  Cell membrane protein-based biomimetic liposomes are designed to mimic natural cells properties and functions and replicate their behavior in vivo. We incorporated the cell membrane protein in the nano-size liposomes by using microfluidic chips. Biomimetic liposomes can retain the unique biological functions of the source cells. Thereby, they can overcome biological roadblocks and to enhance targeting specificity and efficient. We will study the effects of cell membrane protein on the formation and structure of biomimetic liposomes, especially surface, and their interactions with cells. Then we will evaluate the performance and targeting of biomimetic liposomes in drug delivery. Our project will give a meaningful perspective for targeted drug delivery model. 

Chunhuan Liu, Kevin Jahnke, Chenjing Yang, Tiffany Chen