Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores

Citation:

Duncanson, W. J. ; Zieringer, M. ; Wagner, O. ; Wilking, J. N. ; Abbaspourrad, A. ; Haag, R. ; Weitz, D. A. Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores. Soft Matter 2012, 8 10636-10640. Copy at http://www.tinyurl.com/mu73cbq
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Abstract:

We use a perfluorinated-dendrimer-dye complex that stabilizes microbubbles as a novel pore-forming agent. We use microfluidics to produce monodisperse emulsions containing a polymer matrix material, a model active, and the perfluorinated complex; upon drying, the emulsions form porous microspheres. This porosity causes the encapsulated model active to be released faster than from non-porous microspheres. Moreover, because of the fluorous features of the pores, we can also attach an additional guest molecule to the pores which is released with a profile that is distinct from that of the encapsulated active. These porous microspheres can encapsulate and controllably release multiple actives; this makes them valuable for applications such as drug delivery and imaging.

Notes:

Times Cited: 9

Last updated on 04/17/2014