Low intensity ultrasound perturbs cytoskeleton dynamics


Mizrahi, N. ; Zhou, E. H. ; Lenormand, G. ; Krishnan, R. ; Weihs, D. ; Butler, J. P. ; Weitz, D. A. ; Fredberg, J. J. ; Kimmel, E. Low intensity ultrasound perturbs cytoskeleton dynamics. Soft Matter 2012, 8 2438-2443. Copy at http://www.tinyurl.com/mp8rubk


Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low intensity ultrasound. These physical changes are caused by very small strains (10(-5)) at ultrasonic frequencies (10(6) Hz), but are closely analogous to those caused by relatively large strains (10(-1)) at physiological frequencies (10(0) Hz). Moreover, these changes are reminiscent of rejuvenation and aging phenomena that are well-established in certain soft inert materials. As such, we suggest cytoskeletal fluidization together with resulting acceleration of cytoskeletal remodeling events as a mechanism contributing to the salutary effects of low intensity therapeutic ultrasound.


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Last updated on 03/10/2015