%0 Journal Article %J Microfluidics and Nanofluidics %D 2013 %T Enhanced-throughput production of polymersomes using a parallelized capillary microfluidic device %A Kim, Shin-Hyun %A Kim, Jin Woong %A Kim, Do-Hoon %A Han, Sang-Hoon %A Weitz, David A %X

We report a parallelized capillary microfluidic device for enhanced production rate of monodisperse polymersomes. This device consists of four independent capillary microfluidic devices, operated in parallel; each device produces monodisperse water-in-oil-in-water (W/O/W) double-emulsion drops through a single-step emulsification. During generation of the double-emulsion drops, the innermost water drop is formed first and it triggers a breakup of the middle oil phase over wide range of flow rates; this enables robust and stable formation of the double-emulsion drops in all drop makers of the parallelized device. Double-emulsion drops are transformed to polymersomes through a dewetting of the amphiphile-laden middle oil phase on the surface of the innermost water drop, followed by the subsequent separation of the oil drop. Therefore, we can make polymersomes with a production rate enhanced by a factor given by the number of drop makers in the parallelized device.

%B Microfluidics and Nanofluidics %V 14 %P 509-514 %G eng %U https://doi.org/10.1007/s10404-012-1069-5