%0 Journal Article %J Chemical Communications %D 2020 %T DNAzyme-powered nucleic acid release from solid supports %A Cao, Ting %A Wang, Yongcheng %A Tao, Ye %A Zhang, Lexiang %A Zhou, Ying-Lin %A Zhang, Xin-Xiang %A Heyman, John A. %A Weitz, DavidA. %X Here, we demonstrate use of a Mg 2+ -dependent, site-specific DNA enzyme (DNAzyme) to cleave oligos from polyacrylamide gel beads, which is suitable for use in drop-based assays. , Here, we demonstrate use of a Mg 2+ -dependent, site-specific DNA enzyme (DNAzyme) to cleave oligos from polyacrylamide gel beads, which is suitable for use in drop-based assays. We show that cleavage efficiency is improved by use of a tandem-repeat cleavage site. We further demonstrate that DNAzyme-released oligos function as primers in reverse transcription of cell-released mRNA. %B Chemical Communications %V 56 %P 647–650 %G eng %U http://xlink.rsc.org/?DOI=C9CC07790A %N 4 %R 10.1039/C9CC07790A