@article {Jarosz20141083,
	title = {Cross-Kingdom Chemical Communication Drives a Heritable, Mutually Beneficial Prion-Based Transformation of Metabolism},
	journal = {Cell},
	volume = {158},
	number = {5},
	year = {2014},
	pages = {1083 - 1093},
	abstract = {
	Summary In experimental science, organisms are usually studied in isolation, but in the wild, they compete and cooperate in complex communities. We report a system for cross-kingdom communication by which bacteria heritably transform yeast metabolism. An ancient biological circuit blocks yeast from using other carbon sources in the presence of glucose. [GAR+], a\&nbsp;protein-based epigenetic element, allows yeast to circumvent this {\textquotedblleft}glucose repression{\textquotedblright} and use multiple carbon sources in the presence of glucose. Some bacteria secrete a chemical factor that induces [GAR+]. [GAR+] is advantageous to bacteria because yeast cells make less ethanol and is advantageous to\&nbsp;yeast because their growth and long-term viability is improved in complex carbon sources. This cross-kingdom communication is broadly conserved, providing a compelling argument for its adaptive value. By heritably transforming growth and survival strategies in response to the selective pressures of life in a biological community, [GAR+] presents a unique example of Lamarckian inheritance.

},
	issn = {0092-8674},
	doi = {http://dx.doi.org/10.1016/j.cell.2014.07.025},
	url = {http://www.sciencedirect.com/science/article/pii/S0092867414009751},
	author = {Daniel~F. Jarosz and Jessica~C.S. Brown and Gordon~A. Walker and Manoshi~S. Datta and W.~Lloyd Ung and Alex~K. Lancaster and Rotem, Assaf and Amelia Chang and Gregory~A. Newby and David~A. Weitz and Linda~F. Bisson and Susan Lindquist}
}
