@article {:/content/aip/journal/bmf/8/4/10.1063/1.4886771, title = {A high-throughput cellulase screening system based on droplet microfluidics}, journal = {Biomicrofluidics}, volume = {8}, year = {2014}, pages = {041102 }, abstract = { A new ultra-high-throughput screening assay for the detection of cellulase activity was developed based on\ microfluidic\ sorting. Cellulase activity is detected using a series of coupled\ enzymes\ leading to the formation of a fluorescent product that can be detected on a chip. Using this method, we have achieved up to 300-fold enrichments of the active population of\ cells\ and greater than 90\% purity after just one sorting round. In addition, we proved that we can sort the cellulase-expressing\ cells\ from mixtures containing less than 1\% active\ cells. }, doi = {http://dx.doi.org/10.1063/1.4886771}, url = {http://scitation.aip.org/content/aip/journal/bmf/8/4/10.1063/1.4886771}, author = {Ostafe, Raluca and Prodanovic, Radivoje and Ung, W. Lloyd and Weitz, David A and Fischer, Rainer} }