@article {1560635,
	title = {Tunable Nanochannels Connected in Series for Dynamic Control of Multiple Concentration-Polarization Layers and Preconcentrated Molecule Plugs},
	journal = {Nano Letters},
	volume = {20},
	number = {12},
	year = {2020},
	pages = {8524-8533},
	abstract = {Integration of ionic permselective medium (e.g., nanochannels, membranes) within microfluidic channels has been shown to enable on-chip desalination, sample purification, bioparticle sorting, and biomolecule concentration for enhanced detection sensitivity. However, the ion-permselective mediums are generally of fixed properties and cannot be dynamically tuned. Here we study a microfluidic device consisting of an array of individually addressable elastic membranes connected in series on top of a single microfluidic channel that can be deformed to locally reduce the channel cross-section into a nanochannel. Dynamic tunability of the ion-permselective medium, as well as controllability of its location and ionic permselectivity, introduces a new functionality to microfluidics-based lab-on-a-chip devices, for example, dynamic localization of preconcentrated biomolecule plugs at different sensing regions for multiplex detection. Moreover, the ability to simultaneously form a series of preconcentrated plugs at desired locations increases parallelization of the system and the trapping efficiency of target analytes.},
	url = {https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.0c02973},
	author = {Sabbagh, Barak and Stolovicki, Elad and Park, Sinwook and Weitz, DavidA. and Yossifon, Gilad}
}
