@article {155331,
	title = {Low intensity ultrasound perturbs cytoskeleton dynamics},
	journal = {Soft Matter},
	volume = {8},
	number = {8},
	year = {2012},
	pages = {2438-2443},
	abstract = {
	Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low intensity ultrasound. These physical changes are caused by very small strains (10(-5)) at ultrasonic frequencies (10(6) Hz), but are closely analogous to those caused by relatively large strains (10(-1)) at physiological frequencies (10(0) Hz). Moreover, these changes are reminiscent of rejuvenation and aging phenomena that are well-established in certain soft inert materials. As such, we suggest cytoskeletal fluidization together with resulting acceleration of cytoskeletal remodeling events as a mechanism contributing to the salutary effects of low intensity therapeutic ultrasound.

},
	url = {https://pubs.rsc.org/en/content/articlelanding/2012/SM/c2sm07246g$\#$!divAbstract},
	author = {Mizrahi, Natalya and Zhou, Enhua H. and Lenormand, Guillaume and Krishnan, Ramaswamy and Weihs, Daphne and James P. Butler and Weitz, David A and Jeffrey J. Fredberg and Kimmel, Eitan}
}
