@article {154876,
	title = {Polymersomes containing a hydrogel network for high stability and controlled release},
	journal = {Small},
	volume = {9},
	number = {1},
	year = {2013},
	pages = {124-131},
	abstract = {
	Capillary microfluidic devices are used to prepare monodisperse polymersomes consisting of a hydrogel core and a bilayer membrane of amphiphilic diblock-copolymers. To make polymersomes, water-in-oil-in-water double-emulsion drops are prepared as templates through single-step emulsification in a capillary microfluidic device. The amphiphile-laden middle oil phase of the double-emulsion drop dewets from the surface of the innermost water drop, which contains hydrogel prepolymers; this dewetting leads to the formation of a bilayer membrane. Subsequently, the oil phase completely separates from the innermost water drop, leaving a polymersome. Upon UV illumination of the polymersome, the prepolymers encapsulated within the interior are crosslinked, forming a hydrogel core. The hydrogel network within the polymersomes facilitates sustained release of the encapsulated materials and increases the stability of the polymersomes through the formation of a scaffold to support the bilayer. In addition, this approach provides a facile method to make monodisperse hydrogel particles directly dispersed in water.

},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201201709},
	author = {Kim, Shin-Hyun and Kim, Jin Woong and Kim, Do-Hoon and Han, Sang-Hoon and Weitz, David A}
}
