@article {1535369,
	title = {J-Aggregate-Based FRET Monitoring of Drug Release from Polymer Nanoparticles with High Drug Loading},
	journal = {Angewandte Chemie},
	volume = {59},
	number = {45},
	year = {2020},
	pages = {20065-20074},
	abstract = {Understanding drug-release kinetics is critical for the development of drug-loaded nanoparticles. We developed a J-aggregate-based F{\"o}rster-resonance energy-transfer (FRET) method to investigate the release of novel high-drug-loading (50 wt \%) nanoparticles in comparison with low-drug-loading (0.5 wt \%) nanoparticles. Single-dye-loaded nanoparticles form J-aggregates because of the high dye-loading (50 wt \%), resulting in a large red-shift (≈110 nm) in the fluorescence spectrum. Dual-dye-loaded nanoparticles with high dye-loading using FRET pairs exhibited not only FRET but also a J-aggregate red-shift (116 nm). Using this J-aggregate-based FRET method, dye-core{\textendash}polymer-shell nanoparticles showed two release processes intracellularly: the dissolution of the dye aggregates into dye molecules and the release of the dye molecules from the polymer shell. Also, the high-dye-loading nanoparticles (50 wt \%) exhibited a slow release kinetics in serum and relatively quick release in cells, demonstrating their great potential in drug delivery.},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202008018},
	author = {Liu, Yun and Yang, Guangze and Song Jin and Zhang, Run and Chen, Peng and Tengjisi and Wang, Lianzhou and Chen, Dong and Weitz, DavidA. and Zhao, Chun-Xia}
}
