@article {1535367,
	title = {Universal Statistical Laws for the Velocities of Collective Migrating Cells},
	journal = {Advanced Biosystems},
	volume = {4},
	number = {8},
	year = {2020},
	pages = {2000065},
	abstract = {Migratory dynamics of collective cells is central to the morphogenesis of biological tissues. The statistical distribution of cell velocities in 2D confluent monolayers is measured through large-scale and long-term experiments of various cell types lying on different substrates. A linear relation is discovered between the variability and the mean of cell speeds during the jamming process of confluent cell monolayers, suggesting time-invariant distribution profile of cell velocities. It is further found that the probability density function of cell velocities obeys the non-canonical\&nbsp;q-Gaussian statistics, regardless of cell types and substrate stiffness. It is the Tsallis entropy, instead of the classical Boltzmann{\textendash}Gibbs entropy, that dictates the universal statistical laws of collective cell migration. The universal statistical law stems from cell{\textendash}cell interactions, as demonstrated by the wound healing experiments. This previously unappreciated finding provides a linkage between cell-level heterogeneity and tissue-level ensembles in embryonic development and tumor growth.},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adbi.202000065},
	author = {Lin, Shao-Zhen and Chen, Peng-Cheng and Guan, Liu-Yuan and Shao, Yue and Hao, Yu-Kun and Li, Qunyang and Bo Li and Weitz, DavidA. and Feng, Xi-Qiao}
}
