@article {1535357,
	title = {Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation},
	journal = {Angewandte Chemie},
	volume = {59},
	number = {12},
	year = {2020},
	pages = {4720-4728},
	abstract = {Poor solubility often leads to low drug efficacy. Encapsulation of water-insoluble drugs in polymeric nanoparticles offers a solution. However, low drug loading remains a critical challenge. Now, a simple and robust sequential nanoprecipitation technology is used to produce stable drug-core polymer-shell nanoparticles with high drug loading (up to 58.5 \%) from a wide range of polymers and drugs. This technology is based on tuning the precipitation time of drugs and polymers using a solvent system comprising multiple organic solvents, which allows the formation of drug nanoparticles first followed by immediate precipitation of one or two polymers. This technology offers a new strategy to manufacture polymeric nanoparticles with high drug loading having good long-term stability and programmed release and opens a unique opportunity for drug delivery applications.},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201913539},
	author = {Liu, Yun and Yang, Guangze and Baby, Thejus and Tengjisi and Chen, Dong and Weitz, DavidA. and Zhao, Chun-Xia}
}
