@article {du_fan_guo_wang_zheng_huang_liang_gao_cao_chen et al._2019,
	title = {Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4},
	journal = {Cell Systems},
	volume = {9},
	number = {2},
	year = {2019},
	pages = {214-220.e5},
	abstract = {Mechanical factors play critical roles in mammalian development. Here, we report that colony-growing mouse embryonic stem cells (mESCs) generate significant tension on the colony surface through the contraction of a three-dimensional supracellular actomyosin cortex (3D-SAC). Disruption of the 3D-SAC, whose organization is dependent on the Rho/Rho-associated kinase (ROCK) signals and E-cadherin, results in mESC colony destruction. Reciprocally, compression force, which is generated by the 3D-SAC, promotes colony growth and expression of Nanog and Oct4 in mESCs and blastocyst development of mouse embryos. These findings suggest that autonomous cell forces regulate embryonic stem cells fate determination and provide insight regarding the biomechanical regulation of embryonic development.},
	doi = {10.1016/j.cels.2019.05.008},
	url = {https://www.cell.com/cell-systems/retrieve/pii/S2405471219301899?_returnURL=https\%3A\%2F\%2Flinkinghub.elsevier.com\%2Fretrieve\%2Fpii\%2FS2405471219301899\%3Fshowall\%3Dtrue},
	author = {Du, Jing and Fan, Yanlei and Guo, Zheng and Wang, Youguang and Zheng, Xu and Huang, Chong and Liang, Baihui and Gao, Lingyu and Cao, Yanping and Chen, Yunping et al.}
}
