Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

Citation:

Thiele, J. ; Windbergs, M. ; Abate, A. R. ; Trebbin, M. ; Shum, H. C. ; Foerster, S. ; Weitz, D. A. Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer. Lab on a Chip 2011, 11, 2362-2368. Copy at http://www.tinyurl.com/mjxp337
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Abstract:

Early development drug formulation is exacerbated by increasingly poor bioavailability of potential candidates. Prevention of attrition due to formulation problems necessitates physicochemical analysis and formulation studies at a very early stage during development, where the availability of a new substance is limited to small quantities, thus impeding extensive experiments. Miniaturization of common formulation processes is a strategy to overcome those limitations. We present a versatile technique for fabricating drug nanoformulations using a microfluidic spray dryer. Nanoparticles are formed by evaporative precipitation of the drug-loaded spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles of 20-60 nm in diameter are prepared with a narrow size distribution. We design the device with a geometry that allows the injection of two separate solvent streams, thus enabling co-spray drying of two substances for the production of drug co-precipitates with tailor-made composition for optimization of therapeutic efficiency.

Notes:

Times Cited: 8

Last updated on 04/16/2014