Citation:
Windbergs, M. ; Weitz, D. A. Drug dissolution chip (DDC): A microfluidic approach for drug release. Small 2011, 7 3011-3015. Copy at http://www.tinyurl.com/yyn4dd9a
windbergs2011.pdf | 749 KB |
Abstract:
The first pharmaceutical dissolution testing device for multiparticulate drug delivery systems on a microfluidic chip is presented. This versatile platform technology allows for simultaneous analysis of the drug concentration in the dissolution medium and of the solid parts of the sample immobilized in the device with different analytical techniques. By mimicking the fate of drug release in the human body, this can contribute to the optimization of therapeutic effectiveness during the development of novel drug release systems.