Chao Ma from Weitz lab gave a talk at Squishy Physics in Pierce Hall room 209 at 6 PM Feb 26 2020. The title and abstract are below.
Supercharged proteins in biology and chemistry for advanced materials.
Abstract: Over the past few years, mounting interests have been attracted in topics involving intrinsically disordered proteins (IDP). Particularly in the fields of protein engineering, supramolecular self-assembly, functional hydrogels and biomechanics, sophisticated design and manufacturing are realized through amalgamating the IDPs with bioactive components. As one type of the most important IDPs, elastin presents multiple extraordinary properties, including good biomechanical characteristics, biopolymeric phase separation behavior, biodegradability and low immunogenicity. These promising features allow elastin-like proteins to be developed as a new generation of functional biomaterials in the context of cross-disciplinary studies. However, it is challenging to supercharge elastin variants for macroscopic assembly of advanced materials. This talk will highlight recent technical advances and practical applications employing Supercharged elastin-like Proteins (SUPs). First, I will introduce the interplay between SUPs and surfactants and soft matter ensembles generated through the two-component complexation. Second, an artificial tongue consisting of SUPs and polyelectrolyte elements for whiskey discrimination will be underscored. Lastly, a recent finding on etiology of Alzheimer’s disease and elastin would be presented